Similarly, the rats given 50mgkg indomethacin presented several degrees of gastric mucosa lesions. Jan 23, 2002 in the present study this drug was tested for its antiulcerogenic effect. Tetramethylpyrazine ameliorates indomethacininduced. Gastroprotective effects of albizia anthelmintica leaf. Jan 01, 2015 this study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats. Gastric ulcers are among the most common diseases affecting humans. Antiulcerogenic mechanism of magnesium in indomethacin. One group only received ind as negative control group and other group received normal saline and considered. The treated rats were sacrificed by cervical dislocation 4 h later, and the abdomen opened through midline incision. Research article the protective effect of testosterone on.
The fruit pulp was extracted with ethanol and the anti ulcer activity of the extract in indomethacin induced gastric ulceration in swiss albino rats was evaluated. Antioxidant activity of carica papaya seed extracts on. Rosmarinic acid enriched fraction from perilla frutescens. Vitex doniana leaves in indomethacin induced ulcer model in experimental rats. Nebivolol prevents indomethacininduced gastric ulcer in rats. Antiulcerogenic activity of hydromethanolic extract of. Ind, a noncorticosteroid drug, induces ulcerative gastric damage.
Recent efforts have been focused on determining safer alternative nontoxic and natural forms of anti ulcer treatments. Gastroprotective effect of methanolic extract of gomphrena. Nebivolol prevents indomethacininduced gastric ulcer in rats nahla e. Indomethacin inm induced small intestinal ulcers sius induction of small intestinal ulceration was performed according to the previously reported procedure 23. Protective pathways and antisecretory mechanism katary ma1 and salahuddin a2 1department of pharmacology and toxicology, damanhour university, damanhour, egypt 2department of biochemistry, damanhour university, damanhour, egypt corresponding author. Nutrients free fulltext gastroprotective and healing. Protective effects of trigonelline against indomethacininduced. The rats were housed in normal laboratory conditions temperature 22 c and relative humidity 5055% with 12 h lightdark cycle for one week before starting the experiments. Considering the beneficial properties of this plant, we tried to examine the antiulcerative effects of z. Polygonum cuspidatum is widely used as food and medicine in korea, china, and japan.
Group 1 received vehicle 5% tween 80 orally for 8 days. The protective role of menthone against indomethacin. Table 2 summarizes the results obtained in the experimental model of indomethacin induced gastric ulceration in rats. Materials and methods male donryu rats, weighing 260280 g at the time of ulcer induction, were used. Antiulcerogenic effect of genistein against indomethacin induced gastric ulcer in rats ihab t abdelraheem1,2, ghazi a bamagous3, gamal a omran4 1department of pharmacology and toxicology, faculty of pharmacy, damanhour university, damanhour 22111, egypt. The rats were deprived of feed twentyfour hours prior to the commencement of ulcer induction though there was free access to water. Prior to the induction of gastric ulcer, all rats were fasted for. The antiulcer activity of hydromethanolic extract of andrographis culata ape was investigated using 36 rats. Six hours after indomethacin treatment, changes in the gross lesion scores, fundic histopathology, mpo activity and antioxidant activities were observed. Group 2 indomethacin, rats were given oral administration of indomethacin at a concentration of 15 mgkgbody weight0. Indomethacin induced ulcer in hundred percent of the control animals. In this study, we investigated the protective effect of selenium sel, grape seed extract gse, and both on ind induced gastric mucosal ulcers in rats. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats. Rats were divided into six groups with six rats in each group.
Kangwan n1, pintha k2, lekawanvijit s3, suttajit m2. Lercanidipine inhibited the indomethacin induced reduction of cox1 activity. Group a served as the baseline control, gastric ulcer was induced in all the other groups by administering a single dose of 60 mgkg body weight of indomethacin with or without prior 3day. Anti ulcer activity methods indomethacin induced gastric ulcer albino rats of either sex weighing between 150175gm were housed in group of six in standard laboratory housing condition prior to experimentation. The volume and acidity of the gastric juice decreased in the pretreated rats. A metabolomic study to identify potential tissue biomarkers.
Its major bioactive components, resveratrol and emodin, reportedly protect against gastric lesions. Research article the protective effect of testosterone on indomethacin induced gastric ulcer in female sprague dawley rats u. Gastric ulcers were induced in the different groups of rats by indomethacin. The stomach of each rat was washed with icecold saline and blotted dry.
This study aimed at investigating the gastroprotective effects of manuka honey against ethanol induced gastric ulcers in rats. Yohimbine signicantly blocked the anti ulcer effect of bromocriptine and increased the score to 6a50 ae 0a43. Furthermore, the poor gastric ulcers observed at dose 30mgkg and the very severe gastric ulcers at 50mgkg may be explained by the fact that usually, dosage determines effects. The rats had free access to standard rodent food and water ad libitum.
Quercetin is considered to be an antioxidant with healing effects on many experimental toxic injuries. Pdf gastroprotective and antioxidant effects of usnic acid. Lercanidipine changed the oxidantantioxidant balance in favour of the antioxidants. This study aimed to evaluate the effects of menthone, as a novel agent, on gastric ulcers in indomethacin induced model rat. The leaves were extracted with methanol and anti ulcer activity was evaluated for effects on indomethacin induced gastric ulceration.
The rats were killed 6 h after indomethacin administration. The gastroprotective effect of nacetylcysteine and genistein in. This study was undertaken to determine the healing of ulcers induced by indomethacin ind due to the protective role of asafoetida on ulcers in rats. Mar 04, 2019 rosmarinic acid enriched fraction from perilla frutescens leaves strongly protects indomethacin induced gastric ulcer in rats. The antiulcer activity of garcinia cambogia extract.
Pdf gastroprotective effects of albizia anthelmintica leaf. Each rat to receive nebivolol and omeprazole was given the agent orally by gavage daily for 10 days prior to induction of ulcer by oral dosing with indo. Quercetin attenuates, indomethacininduced acute gastric. Gastroprotective effects of albizia anthelmintica leaf extract. Acute gastric ulceration was induced by ind 35 mgkg. Omeprazole 20 mgkg were used as a standard drug for this study. In view of these results, it can be suggested that ua is a cytoprotective compound. The total surface area of ulceration obtained with control was 147. In this group, rats were fasted 24 h and then indomethacin was administrated orally through the gastric gavages 20 mgkg. Tetramethylpyrazine ameliorates indomethacininduced gastric. Experimental design the gastric ulcer was induced using indomethacin single dose, 60 mgkg body weight according to a method described previously 14. They were usually fasted for a period of 2439 hours, allowing free excess to. Pdf gastroprotective and antioxidant effects of usnic. Osifo 2 department of health promotion and education, faculty of.
Gastroprotective and antioxidant effects of usnic acid on indomethacin induced gastric ulcer in rats. To study the persistence of the effect of indomethacin, the animals were killed 2, 4, 6, 12, or 24 h after a single or final administration. The pretreatment were continued for 14 days, at the end of the 14th day, rats from group two to group 6 were kept fasting for 24 hrs and indomethacin were administered orally. The antiulcer activity of garcinia cambogia extract against. Ellagic acid facilitates indomethacininduced gastric ulcer healing. Selim department of biochemistry, faculty of pharmacy, tanta university, tanta, elgharbia, egypt abstract gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. Pretreatment of rats with sulpiride, 60 min before injection of indomethacin, had no effect on indomethacin induced gastric damage 8a40ae 0a42, table 1. This newly established model will be useful for studying the pathogenesis of duodenal ulcers and for screening antiulcer agents. Effect of hydrotalcite on indometacininduced gastric injury. Three groups received indomethacin 30 mgkg body weight orally by orogastric gavage on two consecutive days.
Gastroprotective effect of garlic in indomethacin induced. Therefore, the present study was conducted to evaluate the therapeutic potential of vanillin in peptic ulcer induced by indomethacin using ranitidine as a reference standard drug. Investigations of indomethacininduced gastric ulcer in rats pubmed. Agomelatine prevents indomethacininduced gastric ulcer in rats. A new model of duodenal ulcers induced in rats by indomethacin plus histamine gastroenterology. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight b. The protective activity of trg against indomethacininduced gastric ulcer has been. Ficus exasperata against indomethacin induced gastric ulcer in rats. The protective effect of testosterone on indomethacin induced gastric ulcer in female sprague dawley rats u. Pdf indomethacininduced gastric ulceration in rats.
The protective effect of lercanidipine on indomethacin. Group iv bmmscs treated group, rats with gastric ulcer were injected with bmmscs in the rat tail vein. Antiulcerogenic effect of genistein against indomethacin induced gastric ulcer in rats ihab t abdelraheem1,2, ghazi a bamagous3, gamal a omran4 1department of pharmacology and toxicology, faculty of pharmacy, damanhour. Seven groups a g of five animals were used for this study. The protective roles of butein on indomethacin induced gastric. Department of physiology, college of medicine, university of ibadan, ibadan, nigeria. Thirty minutes after administration of the rice extract, rats were orally administered 30 mgkg indomethacin dissolved in 3% nahco 3 to induce gastric lesions. In our study, the gastroprotective effect of aged garlic extract age and the possible underlying mechanisms were investigated in an experimental model of indomethacin induced gastric ulcer. In contrast to indomethacin, in the present study, the administration of ua and ranitidine reversed the trend table 3. Experimental design the gastric ulcer was induced using indomethacin single dose, 60 mgkg body. Nsaids drugs use in pain management have been linked with ulcer and employed in several animal experiments, but the ulcer dose has been conflicting.
The rats were fasted for 24 hr before the indomethacin administration with free access to water. They were kept in wire meshed cages, fed with commercial rat pellets, and had. Materials and methods animal grouping forty adult male albino rats 150250 g body weight were obtained from the animal house, faculty. Esect of opipramol on indomethacin induced gastric ulcer in rats the antiulcer activities of diserent doses of opipramol were investigated in an indomethacin induced ulcer model in rats. Antiulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats adewoye e. Animals were administered inm10 mg5 ml kg by subcutaneous injection. Rats were divided into four groups with five rats in each group. All the frac tions exhibited varying degrees of antiulcer activity will the order of potency being fif4f5f2f3. Ulcer model for ulcer model induction in rats previously described indomethacin ulcer model was used with no modification17,18. Thirty rats were divided into 5 groups 6 rats group. The gastric mucosa is continuously exposed to various agents like food condiments, spices, alcohol, acids and.
Gastroprotective and ulcer healing effects of piptadeniastrum. Aug 01, 2020 indomethacin exposed rats were given only indomethacin at a dose of 25 mgkg intraperitoneally while all other pretreatments either with omeprazole 30 mgkg or tmp 15, 30 and 60 mgkg were given orally one hour before indomethacin administration. After four hours of administration, the animals were sacrificed and the stomach removed. It was proven that indomethacin causes serious gastrointestinal injury and oxidative stress 27, 28. Effect of feronia elephantum corr fruit pulp extract on. Briefly, inm was suspended in saline with a drop of tween 80 wako, osaka, japan. Indomethacin ind is a nonsteroid antiinflammatory agent that is known to induce severe gastric mucosal lesions.
The rats received famotidine 50 mgkg body weight, quercetin 50 mgkg body weight, or vehi cle alone for 15 consecutive days by oral gavage. The pathogenesis of nonsteroidal antiinflammatory drugs nsaids induced ulceration is still not completely understood, but it is possible that these effects are. Effect of ferula assa foetida oleogumresin on gastric ulcer. Ulcerated rats were orally administered with esomeprazole a reference drug at a dose of 20mgkg body weight, and spondias mombin and ficus. Rats of female sex weighing between 150 g 200 g were used. Three different doses of igm extract 200, 100 and 50 mgkg were orally administered once 30 min before indomethacin treatment. Indomethacin was administered per os to different groups of rats in a dosage of 40 mgkg of body weight each. Protective effects of bk1202 on the indomethacininduced. While only a rat among the rats given 30mgkg indomethacin showed mild form of ulcer, all the rats given 40mgkg indomethacin presented ulcerated gastric mucosa. Ulceration was induced by a single oral administration of indomethacin 30mgkg body weight b.
Fruit pulp extract on indomethacininduced gastric ulcer in albino. Therefore, the present study was undertaken to extend this finding by examining the effects of quercetin on indomethacin induced gastric lesions in rats. Comparative evaluation of the efficacy of cardiospermum. Methods gastropathy was induced in c57bl6 mice or their adhesion. Peptic ulcer diseases are common and are induced by many factors, including stress, smoking, and ingestion of nonsteroidal antiinflammatory drugs. The area of ulcer formation in rats given lercanidipine was smaller. Ulceration was induced by a single oral admin istration of indomethacin 30 mgkg body weight. Osifo 2 department of health promotion and education, faculty of public health, university of ibadan, ibadan, nigeria.
Research article histological and histomorphometric studies. The preventive effect of nigella sativa seed on gastric. Antioxidant, antiinflammatory, and antiulcer potential of. Effect of moringa oleifera leaves extract on the oxidative. Pdf antiulcer effect of bromocriptine on indomethacin. Antiulcer effect of aloe vera in nonsteroidal anti. The parameters assessed were ph and acid concentration of gastric contents, and gastric ulcer. Show full abstract indomethacin induced gastric ulcer in rats. Effect of selenium and grape seed extract on indomethacin. Based on this objective, three varying doses 30, 40 and 50mgkgbw of indomethacin were respectively given orally to. The use of novel agents has been considered for management of different diseases.
The rats were divided into six groups, each containing six animals and fasted for 24 h. Delayed healing of acetic acidinduced gastric ulcers in rats. The mechanism by which honey exerts its antiulcer potential was elucidated. Parenteral and oral treatments were done 1 and 2 hours, respectively before gastric ulcer induction by indomethacin 25 mgkg, i.
Effect of ferula assa foetida oleogumresin on gastric. Gastroprotective effect of vanillin on indomethacin induced gastric ulcer in rats. Anti ulcer effect of ocimum gratissimum on indomethacin induced ulcer and percentage of superoxide dismutase on wistar rats. Delayed healing of acetic acidinduced gastric ulcers in. Interestingly, ukwe et al 2010 had in an earlier study, used 40mgkgbw of indomethacin to induce ulcer in rats. Medications to prevent the development of nsaid induced gastric ulcers have a large range of unpleasant side effects. Gastroprotective effect of vanillin on indomethacininduced gastric. We determined that na prevented ulcer formation, inflammation and apoptosis, and for these reasons, it significantly inhibited ind induced ulcers in rats. Research article histological and histomorphometric. Gastroprotective and antioxidant esects of opipramol on. The parameters assessed were ph and acid concentration of gastric contents, and gastric ulcer index.
Nsaid induced ulcer model is one of the the most commonly used gastric ulcer models19. The gastric ulcer was induced using indomethacin single dose, 60 mgkg body weight according to a me thod described previously 14. Pdf spondias mombin linn anacardiaceae and ficus exasperata. Research paper intestinal and hepatic expression of. Animals were randomly divided into six groups 10 rats each as follows.
The mechanism of indomethacininduced gastric ulcer healing by ellagic acid ea in experimental mice model is described in our study. After 6 hours of indomethacin administration, rats were. Oral pretreatment with garcinia cambogia fruit extract 1 gkg body wtday for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin 20 mgkg body wt. Briefly, each rat received 1 ml of 1% wv evans blue in sterile saline. The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight. In normal rats, indomethacin was administered subcutane ously once at 1 mgkg or repeatedly for 2 or 4 wk once daily at 1 mgkg. Peptic ulcer was induced in all the rats using indomethacin at 50mgkgbw single dose and the level of total endogenous anti oxidants were significantly p0. Indomethacin 5 mgkg was first given subcutane ously to rats fasted for 24 h, and subsequently histamine dihydrochloride 40 mgkg was given subcutaneously three times, at 2. Indomethacin induced gastropathy in cd18, intercellular adhesion. This study investigated the gastroprotective effects of na in an ind induced gastric acid model in rats. Effect of methanolic leaf extract of cissampelos mucronata a. The protective role of menthone against indomethacininduced. An equal volume of distilled water was administered to the control group as a vehicle.
Spraguedawley rats 200250 g were given sel, gse, and both by oral gavage for 28 days, and then gastric ulcers were. Indomethacin induced gastric ulcer model was established in rats. Protective effects of quercetin and melatonin on indomethacin. In the present study, the significant increase in ulcer index and gastric volume following oral administration of indomethacin in the ulcerated rats may be attributed. Gastroprotective effects of glutinous rice extract against. In this regard, an animal model experiment was carriedout to determine the ulcer dose of indomethacin on female wistar rats. Gastroprotective mechanisms of imipramine on indomethacin. Pdf gastroprotective effects of albizia anthelmintica. In this study, 72 male wistar rats were randomly divided into 12 groups, six in each including. Protective effects of naringin in indomethacininduced.
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